V. Agrawal, S. Sachan, P. Khadikar
2000
Citations
0
Influential Citations
23
Citations
Journal
Acta Pharmaceutica
Abstract
H 1 -antagonistic activity for a series of 2-(4-and 3- substituted phenyl(3-[3-(N,N-dimethylamino)propyl]-1,3-thiazolidine-4-ones was modelled using molecular redundancy (MRI) and first-order valence connectivity ( 1 X v ) indices. The results have shown that antagonist potency (pA 2 ) could be modelled in multiparametric correlation on introduction of dummy parameters Ip 1 and Ip 2 (indicator parameters). Weighted Wiener and Szeged indices (Ww and Szw) were used as substituent parameters.