James M. Glass, R. Stephen, S. Jacobson
Nov 1, 1980
Citations
1
Influential Citations
154
Citations
Quality indicators
Journal
International Journal of Dermatology
Abstract
ABSTRACT: A pilot study was conducted in the first of two monkeys using either radiolabeled Dm‐Na‐P or radiolabeled hydrocortisone sodium succinate, together with lidocaine HCI. This study indicated an approximately tenfold increase in the quantity of Dm‐Na‐P delivered to the test electrodes (4 mA; 20 minutes) whereas the quantity of hydrocortisone delivered from the test electrodes was only marginally (≅10%) increased as compared with that from the controls. In terms of an antiinflammatory activity, the effective dose of Dm‐Na‐P in all tissue layers underlying the test electrodes was at least tenfold that of the hydrocortisone. Therefore, further trials with hydrocortisone were abandoned.