J. Guiles, Xicheng Sun, I. Critchley
Feb 1, 2009
Citations
0
Influential Citations
28
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
High throughput screening led to the discovery of a novel series of quinazolin-2-ylamino-quinazolin-4-ols as a new class of DNA polymerase III inhibitors. The inhibition of chromosomal DNA replication results in bacterial cell death. The synthesis, structure-activity relationships and functional activity are described.