J. S. Lee, A. W. Anderson, P. R. Elliker
Aug 1, 1963
Citations
0
Influential Citations
31
Citations
Quality indicators
Journal
Radiation research
Abstract
The sulfhydryl group combining agents, N-ethylmaleimide (NEM) and iodoacetic acid (IAA), were investigated for their abilities to enhance gamma - radiation inactivation of Micrococcus radiodurans. At the nontoxic level of 100 mu M, the inactivation by irradiation was accelerated with IAA, but no effect was observed with NEM. The removal of O did not produce any detectable changes in the action of either chemical. The accelerated radiolethal effect appears to be due to the highly reactive radiolytic products of IAA and their nonspecific reactions with various cellular constituents.