T. Neubert, Y. Schmidt, Erica Conroy
Apr 27, 2015
Citations
0
Influential Citations
24
Citations
Journal
Organic letters
Abstract
A radical mediated C-H functionalization of 3,6-dichloropyridazine using primary alcohols, t-BuOOH, and TiCl3 to access alkoxy pyridazines is described. This transformation is conducted open to air and on gram scale. A subsequent cyclization step can then be employed to efficiently access diversely substituted tetrahydropyridopyridazines with multiple functional handles.