M. Erfani, M. Rekabgardan, P. Mortazavi
Jun 1, 2016
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Journal
Journal of Radioanalytical and Nuclear Chemistry
Abstract
Gemifloxacin as a broad spectrum quinolone antibacterial agent was radiocomplexed with high activity of 99mTc and was evaluated as an infection imaging agent in artificially Escherichia coli (E. Coli) infected mice. 99mTc-Gemifloxacin with high specific activity (0.148 GBq/μmol) and labeling yield (98.60 ± 0.70 %) was obtained. Our main achievement was high accumulation in the E. Coli infected right thigh muscle in mice (T/NT = 1.89 at 4 h post injection) which may diagnostically be beneficial to distinguish sites of E. Coli infection.