G. Gopalakrishna, Y. W. Lee, S. Selvaraj
Aug 1, 1988
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The aliphatic amines, 2-methyl- and 2-isopropyl- substituted 6-hydroxy −1 -hexylamines were synthesized from ethyl-6-hydroxyhexanoate in 22% and 11% overall chemical yield respectively. 6-hydroxy- 1 -hexylamine was available commercially. 6-hydroxy −1 -hexylamine and its 2-methyl- and 2 -isopropyl- substituents were successfully radioiodinated with trimethylsilyl polyphosphate and [131I]-Nal/Nal to afford the corresponding 6-[131I]-labelled amines in 67%, 61% and 55% radiochemical yield respectively and greater than 98% radiochemical purity (specific activity 340 GBq mmol−1).