C. Tsopelas
Jul 1, 1999
Citations
0
Influential Citations
1
Citations
Journal
Nuclear medicine and biology
Abstract
Abstract 4-Iodo- N -(2-morpholinoethyl)benzamide (1) is a new benzamide that is an analogue of the antidepressant moclobemide. The synthesis of (1) is described and the radiolabelling conditions with Na 123 I and Na 125 I were optimized using the Cu(I)-added exchange labelling reaction. The reaction was found to perform best in the presence of Cu + and a stannous reducing agent, in the absence of Cu 2+ and potassium iodide, and at [H + ] = 1.8–7.9 mM with a ligand (1) concentration=2.6–5.6 mg/mL cold kit. Above a [H + ] of 7.9 mM, the hydrolysis of (1) gave 4-iodo[ 125 I]benzoic acid in high amounts. The radiochemical conversion was routinely >95% and >98% after anion exchange Sep-Pak treatment. The radiolabelled product is stable at room temperature for at least 4 h.