M. Kassiou, W. B. Mathews, J. Musachio
May 1, 1994
Citations
0
Influential Citations
6
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
(±)-1-(2-bromo-4,5-dimethoxybenzyl)-7-hydroxy-6-methoxy-2-[11C]-methyl-1,2,3,4-tetrahydroisoquinoline, (HCJA-69024, a selective ligand for the D1 receptor was prepared by N-alkylation of (±)N-desmethyl A-69024 with [11C]methyl iodide in DMF. The radiotracer was purified by semi-preparative reverse-phase HPLC. The average specific activity was 1950 mCi/μmol calculated at end-of-synthesis (EOS). The average time of synthesis including formulation was 20 minutes.