Feb 2, 2020
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Abstract
An orally bioavailable, small molecule inhibitor of the acetate form of ralaniten, a Nterminal domain (NT D) of the androgen receptor (AR), with potential antineoplastic activity. Upon oral administration of ralaniten acetate, ralaniten specifically binds to the NT D of AR, thereby inhibiting both AR activation and the AR-mediated signaling pathway. T his inhibits cell growth in AR-overexpressing tumor cells. AR is overexpressed in prostate cancers and is involved in proliferation, survival and chemoresistance of tumor cells. Qeios · Definition, February 2, 2020