Shan Xiao-mei
2005
Citations
0
Influential Citations
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Citations
Quality indicators
Journal
Chinese Journal of Infection and Chemotherapy
Abstract
Objective This study was designed to evaluate the efficacy and safety of lenampicillin hydrochloride tablet in the treatment of acute bacterial infections. Methods Amoxicillin capsule was used as control treatment. Forty nine patients were evaluated including 25 in lenampicillin group and 24 in amoxicillin group. The dosage regimen for the two agents was 500 mg, 3 times a day for 7-14 days. Results The cure rate was 68.0% in lenampicillin group and 70.8% in amoxicillin group. The response rate was 90.2% in lenampicillin group and 100% in amoxicillin group. Bacterial eradication rate was 93.3% in lenampicillin group and 70.8% in amoxicillin group. The incidence of adverse reaction was 12.0% in lenampicillin group and 4.2% in amoxicillin group. The difference of all these parameters between the two groups was not statistically significant. Of the 29 pathogenic isolates collected, 89.7% were susceptible to lenampicillin, not significantly different from the susceptibility to amoxicillin, cefuroxime, ciprofloxacin and cefradine. Conclusions Lenampicillin hydrochloride tablet is safe and effective in the treatment of acute bacterial infections.