C. L. Loprinzi, S. Kuross, Judith R. O'Fallon
Jun 1, 1994
Citations
1
Influential Citations
100
Citations
Quality indicators
Journal
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Abstract
PURPOSE Hydrazine sulfate is a controversial agent that was originally studied in cancer patients approximately 20 years ago. Based on a series of recent trials that suggested that this drug might have utility in cancer patients, we conducted this study. PATIENTS AND METHODS Patients with metastatic colorectal cancer were randomized to receive hydrazine sulfate or placebo in a double-blinded manner. Protocol patients did not concurrently receive any other systemic antineoplastic treatment. RESULTS There were 127 assessable patients entered onto this clinical trial. Data from the study showed trends both for poorer survival and for poorer quality of life (QL) in the hydrazine group. There were no significant differences in the two study arms with regard to anorexia or weight loss. CONCLUSION This trial failed to demonstrate any benefit for hydrazine sulfate.