J. Melnick, D. Crowther, J. Barrera-Oro
Aug 25, 1961
Citations
1
Influential Citations
71
Citations
Quality indicators
Journal
Science
Abstract
Guanidine hydrochloride is a potent inhibitor of poliovirus synthesis in cell culture. However, the viral progeny which do grow in the presence of guani-dine may become approximately 10,000 times more resistant to the drug. The phenomenon of drug resistance poses yet another problem in the search for a satisfactory viral chemotherapeutic agent.