C. Khatri, Santoshkumar M. Potadar, G. Chaturbhuj
May 3, 2017
Citations
0
Influential Citations
15
Citations
Journal
Tetrahedron Letters
Abstract
Abstract This is the first-time ammonium thiocyanate (NH 4 SCN) has been used as a self-promoting reactant for the synthesis of 3,4-dihydropyrimidin-2(1 H )-thiones. This report describes a greener, efficient and economic protocol for one pot three-component synthesis of Biginelli compounds using various aldehydes, β-ketoesters and ammonium thiocyanate. Ammonium thiocyanate being a weak acid, accelerate the rate of reaction to obtain Biginelli compounds in solvent-free condition at 110 °C. The key advantages of the present method are high yields, short reaction time, solvent free condition, easy workup and ability to tolerate a variety of functional groups. Ammonium thiocyanate is readily available, cheaper, safer and industrial acceptable material which gives economical as well as ecological rewards to the present method.