V. Kuznetsov, Y. E. Brusilovskii
May 1, 2001
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Journal
Chemistry of Heterocyclic Compounds
Abstract
The reaction of 4-phenyl- and 4,4-dimethyl-1,3-dioxanes with acetone cyanohydrin leads to hydrolytically unstable 2-(1-hydroxy-1-methylethyl)-5,6-dihydro-1,3-oxazines, which are readily saponified in alkaline medium to the corresponding 1,3-amino alcohols.