E. Oishi, C. Sugiyama, K. Iwamoto
Mar 1, 2004
Citations
0
Influential Citations
3
Citations
Journal
Heterocycles
Abstract
The reaction of 1-chloro (3), 1-methylsulfonyl (7) [1,4]benzodioxino[2,3-d]pyridazine and 4-chloro[1,4]benzodioxino[2,3-c]pyridazine (4) with sodium methoxide afforded dioxin ring-opened pyridazines (14 - 16) and ring-cyclized pyridazines (9, 10), while their reaction with amines [n-butylamine (8a), cyclohexylamine (8b), morpholine (8c), piperidine (8d), pyrrolidine (8e), hydrazine (8f) and aniline (8g)] afforded 1-substituted [1,4]benzodioxino[2,3-d]-pyridazines (18), 4-substituted [1,4]benzodioxino[2,3-c]pyridazines (19) and/or 2-hydroxyphenoxypyridazines (20 - 22).