D. Reitz, Michael J. Finkes
1989
Citations
0
Influential Citations
29
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Reaction of 3,5-bis(trifluoromethyl)-1,3,4-oxadiazole (1a) with primary amines under a variety of conditions conveniently produced 4-substituted-3,5-bis(trifluoromethyl)-4H-1.2,4-triazoles 4a in 26-85% yield. Alkyl amines reacted with 1a in methanol at −42° to provide hydrogen-bonded monoadduct-methanol complexes 5a, as determined by X-ray. The reaction of 1a with sterically hindered or strongly electron deficient anilines required high temperatures in the absence of solvent.