U. Urleb, B. Stanovnik, M. Tislér
Feb 1, 1990
Citations
0
Influential Citations
8
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
2-Ethoxycarbonyl-3-isothiocyanatopyridine (1) reacts with α-amino acids 2–11 and β-alanine (12) to give pyrido[3,2-d]pyrimidine derivatives 13–23 with the nitrogen of the amino acid component being incorporated into the fused pyrimidine ring at position 3. Methylation of 14 and 15 with DMFDMA produces S-methylated products 24 and 25, while in the reaction of 14 with hydrazine the corresponding hydrazide 26 is formed. The reactions proceed under mild conditions, so that no racemization of chiral substituents was observed.