S. Manta, Nikolaos Kollatos, C. Mitsos
Jan 3, 2020
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Influential Citations
3
Citations
Quality indicators
Journal
Mini reviews in medicinal chemistry
Abstract
Pyrrole is one of the most important heterocyclic compounds having increasing importance in medicinal chemistry and organic synthesis. It has been widely used as antitumor, anti-inflammatory, antibacterial, antioxidant and antifungal agent. Access to this key heterocycle by multicomponent routes is particularly attractive in terms of synthetic efficiency, and also from the environmental point of view. The present mini review summarizes all published data on methods for the synthesis of highly substituted pyrrole derivatives, based exclusively on the one-pot multicomponent reaction of aldehydes, primary amines and oxalacetate analogues and their biological features.