A. Catino, J. Nichols, Brian J. Nettles
Apr 8, 2006
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0
Influential Citations
148
Citations
Quality indicators
Journal
Journal of the American Chemical Society
Abstract
Dirhodium caprolactamate [Rh2(cap)4] is a highly effective catalyst for the oxidative Mannich reaction. The reaction proceeds via C-H oxidation of a tertiary amine followed by nucleophilic capture. This green transformation is conducted in protic solvent using inexpensive T-HYDRO (70% t-BuOOH in water). Synthetically valuable gamma-aminoalkyl butenolides are obtained.