Zhengbo Zhu, D. Seidel
Jan 19, 2016
Citations
0
Influential Citations
29
Citations
Journal
Organic letters
Abstract
Pyrrolidine and 1,2,3,4-tetrahydroisoquinoline (THIQ) undergo redox-neutral α-amidation with concurrent N-alkylation upon reaction with aromatic aldehydes and isocyanides. Reactions are promoted by acetic acid and represent a new variant of the Ugi reaction.