W. Cullen, B. McBride, J. Reglinski
1984
Citations
4
Influential Citations
207
Citations
Quality indicators
Journal
Journal of Inorganic Biochemistry
Abstract
Abstract Address reprint requests to Dimethylarsinic acid and disodium methylarsonate are easily reduced by thiols in neutral solution to give the organosulfur derivatives of arsenic(III), (CH 3 ) 2 AsSR, CH 3 As(SR′) 2 , or CH 3 AsSR″S (RSH = R′SH = cysteine, glutathione, HSCH 2 CH 2 OH; RSH = HSCH 2 COOH; HSR″SH = dithiothreitol, 6.8-dithiooctanoic acid. The reactions are usually stoichiometric and quantitative: HSCH 2 COOH is an exception, apparently for kinetric reasons. The mechanism appears to be Me x As V O(OH) 3−x + 2RSH → Me x As V (SR) 2 (OH) 3−x + H 2 O Me x As V (SR) 2 (OH) 3−x 4− → Me x As III (OH) 3−x + RSSR Me x As III (OH) 3−x + (3−x)RSH → Me x As(SR) 3−x The possible importance of these reductions in the biological methylation of arsenic is discussed.