B. Ackermann-Schmidt, R. Süssmuth, F. Lingens
Nov 30, 1982
Citations
0
Influential Citations
4
Citations
Journal
Biochimica et biophysica acta
Abstract
The mutagen 1,1'-hexamethylene-bis[(5-p-chlorophenyl)-biguanide] reacts at 37 degrees C with guanosine and guanine to yield xanthosine or xanthine and oxidizes cysteine to cystine. After treatment of a guanosine-labelled DNA sample from Escherichia coli with the mutagen xanthine could be detected as a reaction product. At a slow rate the mutagen is hydrolysed spontaneously yielding urea, 1.6-hexanediol and 4-chloroaniline. The reaction mechanisms both of the hydrolysis and of the reaction with cysteine and guanosine are discussed.