M. Adib, S. Ansari, H. Bijanzadeh
Mar 1, 2011
Citations
1
Influential Citations
23
Citations
Journal
Synlett
Abstract
A multicomponent synthesis of 3,4-disubstituted N-aminopyrrolidine-2,5-diones is described. A mixture of N-isocyaniminotriphenylphosphorane, an aldimine and Meldrum's acid undergoes an addition reaction under mild conditions in aqueous THF to produce I-amino-4-aryl-2,5-dioxo-N 3 -aryl-3-pyrrolidine-carboxamides diastereoselectively in good to excellent yields. 1 H NMR analysis showed that the two substituents on C-3 and C-4 positions of the obtained pyrrolidine-2,5-diones are trans.