M. Memeo, E. Valletta, B. Macchi
Jul 10, 2018
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
ACS Omega
Abstract
Nitrosocarbonyl mesitylene intermediate undergoes an ene reaction with cinnamyl alcohol affording the corresponding 5-hydroxy-isoxazolidine in fair yields. The synthesized 5-acetoxy-isoxazolidine serves as synthon for the preparation of 6-chloropurine N,O-nucleoside analogues, according to the Vorbrüggen reaction. The compounds were evaluated for their metabolic and apoptotic activity, and their structure–activity relationship is discussed.