G. Rao., J. Osborn
Jan 1, 1977
Citations
0
Influential Citations
2
Citations
Quality indicators
Journal
Journal of Dental Research
Abstract
Currently, there is growing awareness that dietary nitrite may interact with orally ingested amino compounds to produce carcinogenic N-nitrosamines (MIRvIsH, Toxicol Appl Pharmacol 31:325-351, 1975; RAO and KRISHNA, I Pharm Sci 64:1579-1581, 1975). Many oral hygiene products contain amino derivatives that could react with nitrite to yield potentially toxic Nnitroso compounds in the oral tissues or in the stomach or in both. In the present study, we evaluated the in vitro and the in vivo formation of N-nitrososarcosine (NS) from the reaction of NaNO2 with sodium N-lauroyl sarcosinate (LS), which has been used as a detergent and antienzyme agent in dentifrices (AMERICAN DENTAL AsSOCIATION, Accepted Dental Therapeutics, 36th ed, 1975, p 306). NS is known to induce esophageal cancer in rats (DRUCKREY, Z Krebsforsch 69:103-201, 1967), and nose and liver carcinomas in mice (WOGAN ET AL, Cancer Res 35:1981-1984, 1975). Since the formation of NS from sarcosine-nitrite reaction has been well established (FRIEDMAN, Bull Environ Contam Toxicol 8: 375-382, 1972) sarcosine was used as a positive control in this study.