Aug 24, 2004
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Influential Citations
11
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Journal
Nucleosides, Nucleotides & Nucleic Acids
Abstract
Reaction of 2‐hydrazinopyridine (1) with d‐xylose, d‐galactose, d‐glucose and d‐fructose afforded the corresponding hydrazones mainly in the acyclic forms 2, 3, 6 and 11 with minor amounts of the cyclic structures. Oxidative cyclization of the hydrazones with bromine in methanol resulted in the formation of the 3‐(polyhydroxyalkyl)‐1,2,4‐triazolo[4,3‐a]pyridine derivatives 13–15 whose acetylation afforded the acetylated derivatives 16–18. Assignment of 1D and 2D NMR spectral data in addition to 15N NMR experiments led to complete characterization of the products.