S. Malaquin, M. Jida, J. Gesquiere
Jun 2, 2010
Citations
0
Influential Citations
30
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A two-step sequence involving an Ugi four-component reaction was developed for the preparation of 4-aminopiperidine-4-carboxylic acid derivatives. This strategy has led to the successful preparation of two drugs carfentanil and remifentanil in shorter times and better yields than previously described methods.