K. S. Kumar, P. Kumar, K. A. Kumar
May 7, 2011
Citations
1
Influential Citations
94
Citations
Quality indicators
Journal
Chemical communications
Abstract
Concurrent construction of five and six membered fused N-heretocyclic ring was achieved via a conceptually new three-component reaction affording 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-diones as novel inhibitors of TNF-αin vitro. This represents one of the few examples of direct TNF-α inhibition by small molecules.