B. Kalluraya, B. Lingappa, Satheesh Rai Nooji
2006
Citations
1
Influential Citations
2
Citations
Journal
Organic Chemistry: An Indian Journal
Abstract
A new series of 2-(4,6-disubstituted-2-thiomethyl pyrimidyl)-1,3,4- oxadiazole-5-thiones (5a-c) were synthesized. These oxadiazoles can exist both in the thiol as well as in the thione tautomeric form. However when these compounds were subjected to Mannich reaction, N-Mannich bases (6a-r) were obtained rather than the S-Mannich bases. The structures of the new compounds were confirmed by spectral and analytical data. Few of these Mannich bases were evaluated for their possible antifungal and antibacterial activity. Most of the tested compounds showed significant antifungal and antibacterial activity comparable with that of the standard drug.