W. Szarek, G. Hay, B. Doboszewski
Nov 1, 1986
Citations
0
Influential Citations
9
Citations
Journal
Carbohydrate Research
Abstract
The reaction of 1,2-anhydro-3,4:5,6-di-O-isopropylidene-1-C-nitro-d-mannitol (2) with potassium hydrogenfluoride in ethylene glycol under anhydrous conditions provides a route to 2-deoxy-2-fluoro-d-glucose, the 18F-labeled analog of which is an important radiopharmaceutical of use in medical imaging. The reaction is accompanied to a minor extent by epimerization at C-2 of the initially formed fluoro aldehyde and also results in an attack by solvent at C-2 in 2.