R. Yakovenko, V. M. Muzalevskii, V. Nenajdenko
Apr 16, 2015
Citations
0
Influential Citations
6
Citations
Journal
Russian Journal of Organic Chemistry
Abstract
The synthesis and chemical properties of trifluoromethyl-containing enones are subjects of considerable attention [1–10]. A combination of strong electronwithdrawing power of the COCF3 group and C=C bond endows conjugated 1,1,1-trifluorobut-3-en-2ones with unique chemical properties. Taking into account electrophilicity of such structures, reactions with various O-, N-, S-, and C-nucleophiles involving the carbonyl group and/or double carbon–carbon bond have been developed, and new trifluoromethyl-substituted carboand heterocycles, as well as various polyfunctional compounds, have been synthesized [11–15]. However, reactions of 1,1,1-trifluorobut-3-en-2-ones with such π-nucleophiles as arenes have not been studied so far.