L. De Crescentini, F. R. Perrulli, G. Favi
Sep 21, 2016
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Influential Citations
9
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Journal
Organic & biomolecular chemistry
Abstract
Here we describe the reaction of 1,2-diaza-1,3-dienes and propargyl alcohol furnishing α-(prop-2-yn-1-yloxy)hydrazones that are converted into novel alkyl-1-oxa-7,8-diazaspiro[4.4]nona-3,8-dien-6-ones, by means of 2,3-Wittig rearrangement under very mild conditions. The same α-(prop-2-yn-1-yloxy)hydrazones, treated with benzyl azides furnish the corresponding α-[(1,2,3-triazol-4-yl)methoxy]hydrazones, via Cu(ii)-catalyzed 1,3-dipolar cycloaddition. Their subsequent base-promoted cyclization produces interesting pyrazolone-triazole derivatives. The impact of this work can be ascribable to the attractiveness of the bi-heterocyclic systems obtained and to the ease of the synthetic methodologies proposed.