B. A. Lugovik, L. Yudin, P. V. Borodin
Jun 1, 1971
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Journal
Chemistry of Heterocyclic Compounds
Abstract
The addition of benzene to 2,2,4-trimethyl-1,2-dihydroquinoline (I) in the presence of AlCl3 requires prior protonation or acylation of the amino group. Electron-donor substituents in the benzene ring of I hinder the reaction. The addition of halobenzenes proceeds under more severe conditions to give only para-substituted 4-aryl-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolines.