L. V. Baichurina, N. I. Aboskalova, E. V. Trukhin
Apr 20, 2011
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Journal
Russian Journal of General Chemistry
Abstract
Reactions of α-nitrocinnamic acids esters with indole and its derivatives lead to the formation of the products of alkylation at the C3-reaction center of the heterocycle. The hydrogenation of the adduct of 1-methylindole and α-nitro-β-phenylacrylate on the Raney nickel catalyst afforded indolylaminopropanoate, that was used for the synthesis of ethyl 2-acetylamino-3-(1-methylindol-3-yl)-3-phenylpropanoate, a precursor of the methylated in the indole ring phenyl-substituted tryptophan.