M. M. Burbulienė, E. Udrenaite, P. Gaidelis
Aug 13, 2002
Citations
0
Influential Citations
6
Citations
Journal
ChemInform
Abstract
From 2,4-dichloro-6-methylpyrimidine (1) via esters 2 and 3, (2-dimethylamino-6-methyl-4-pyrimidinylsulfanyl)acethydrazide (4) was synthesized. The latter under treatment either with carbon disulfide in the presence of a base or with potassium O-ethylxanthate in ethanol yielded 5-(2-dimethylamino-6-methyl-4-pyrimidinylsulfanylmethyl)-1,3,4-oxadiazole-2-thione (5). Alkylation of 5 afforded S-alkyl derivatives 6a,b, whereas aminomethylation, acylation or cyanoethylation gave N ( 3 ) -substituted derivatives 7-9. Compounds were tested for their anti-inflammatory activity.