Y. Gol'dfarb, A. P. Yakubov, L. I. Belen’kii
Jun 1, 1986
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Journal
Chemistry of Heterocyclic Compounds
Abstract
The reaction of 2-thiophene aldehyde, 2-acetylthiophene, 2-thiophene carboxylic acid, and its methyl ester with N-(hydroxymethyl)chloroacetamide in concentrated sulfuric acid yields a mixture of 4- and 5-(N-chloroacetylamino) methyl derivatives, the former being preferred.