A. Detsi, J. Markopoulos, O. Igglessi-Markopoulou
1996
Citations
0
Influential Citations
16
Citations
Journal
Chemical Communications
Abstract
The N-hydroxysuccinimide esters of N-alkoxycarbonyl-α-amino acids react with active methylene compounds (cyanoacetic esters, malonic and acyl acetic esters), under basic conditions, to produce 3-substituted N-alkoxycarbonyl tetramic acids; in the case of the N-hydroxysuccinimide esters derived from L-aminoacids, the corresponding optically active tetramic acids are obtained.