Michel Baboulene, G. Sturtz
Sep 1, 1978
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0
Influential Citations
7
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Journal
Phosphorus Sulfur and Silicon and The Related Elements
Abstract
Abstract Nous avons etudie la reactivite du bromo-3 oxo-2 propyl phosphonate de diethyle mis dans les conditions de la reaction de Hantzsch. Divers heterocycles thiazoliques et imidazothiazoliques ont ainsi ete obtenus. Testes dans plusieurs domaines biologiques (radio-protection, systeme nerveux central, phytosanitaire) ces composes n'ont presente aucune activite therapeutique interessante. The reactivity of diethyl 3-bromo 2-oxo propene phosphonate is studied in experimental conditions of the Hantzsch reaction. Various thiazolyl and imidazothiazolyl heterocycles have been obtained. In the pharmacology screening (radioprotection, C.N.S. properties,…) these compounds did not show any potential therapeutic activity.