M. A. Khalil, S. Sayed, M. Raslan
Dec 1, 2012
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Abstract
Treatment of 2-cyano-N-(4-(1-methyl-1H-benzo(d)imidazo l-2-y l)-3-(methylthio)-1-phenyl-1H-pyrazol-5-yl) acetamide (4) with phenyl isothiocyanate gave the thiole derivative (6) which on treat ment with hydrazonyl chlorides (7a-c) furnished 1,3,4-th iadiazole derivatives (9a-c). React ion of cyanoacetamide derivative (4) with active methylene reagents such as malononitrile o r ethyl cyanoacetate and elemental sulfu r afforded the corresponding polysubstituted thiophene derivatives (18a,b). Reaction of cyanoacetamide derivative (4) with benzaldehyde yielded the phenylmethylidene derivative (21). The latter showed interesting reactivity towards cyanomethylene reagent and hydrazine derivatives afforded pyrane (22a,b) and pyrazole (25a,b) derivatives.