Li-Hong Zhou, Xiao‐Qi Yu, L. Pu
Mar 6, 2009
Citations
1
Influential Citations
22
Citations
Journal
The Journal of organic chemistry
Abstract
A convenient synthesis of the optically active 4-amino-2(5H)-furanones is discovered by combining an asymmetric alkyne addition to aldehydes and a subsequent aliphatic amine addition. Both steps can be conducted at room temperature and the products are obtained with high enantioselectivity (84-90% ee). The 4-amino-2(5H)-furanones are also found to undergo very facile electrophilic substitution reactions.