A. Breccia, F. Busi, E. Gattavecchia
1990
Citations
0
Influential Citations
8
Citations
Quality indicators
Journal
Radiation and Environmental Biophysics
Abstract
SummaryA new series of nitrothiophene derivatives have been synthetized and some of the physico-chemical parameters which can influence both their radiosensitizing efficiency and toxicity have been investigated. These include octanol/water partition coefficient (P), one-electron reduction potential (E71) and reactivity of the drugs towards primary radical species. For these studies, pulse radiolysis techniques and conventional polarography have been extensively used. Biological responses (both sensitization and toxicity) have been tested towards Chinese Hamster cells in vitro. The results are valuable in selecting, among the tested compounds, 5-NTMA, 5-NTM, 4- and 5-NTCA as the nitrothiophenes promising for in vivo applications.