P. Fier, Suhong Kim, R. Cohen
Mar 31, 2020
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Influential Citations
24
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Journal
Journal of the American Chemical Society
Abstract
We report the development of a multifunctional reagent for the direct conversion of pyridines to Boc-protected 2-aminopyridines with exquisite site- and chemoselectivity. The novel reagent was prepared on 200 gram-scale in a single step, reacts in the title reaction under mild conditions without precautions towards air or moisture, and is tolerant of nearly all common functionality. Experimental and in-situ spectroscopic monitoring techniques provide detailed insights and unexpected findings for the unique reaction mechanism.