E. Felder, A. Gallotti, A. Favilla
Sep 1, 1988
Citations
0
Influential Citations
2
Citations
Journal
Investigative Radiology
Abstract
: Iomeprol, a new nonionic contrast agent, undergoes in alkaline solution a Smiles-type intramolecular rearrangement to give 5-methylaminocarbonylmethoxy-2,4,6-triiodoisophthalic acid-bis-(2,3-dihydroxypropylamide). The rearranged product was isolated and its structure confirmed by spectra and by synthesis. The reaction is reversible and could be extended to some structurally related compounds.