E. Felder, A. Gallotti, A. Favilla
Sep 1, 1988
Citations
0
Influential Citations
3
Citations
Journal
Investigative Radiology
Abstract
Felder E, Gallotti A, Favilla A. Molecular rearrangement of 5‐(a‐hydroxy‐alkanoylamino)‐2,4,6‐triiodo‐isophthalic acid amides. Invest Radiol 1988;23(Suppl 1):S101‐S105. Iomeprol, a new nonionic contrast agent, undergoes in alkaline solution a Smiles‐type intramolecular rearrangement to give 5‐methylaminocarbonylmethoxy‐2,4,6‐triiodoisophthalic acid‐bis‐(2,3‐dihydroxypropylamide). The rearranged product was isolated and its structure confirmed by spectra and by synthesis. The reaction is reversible and could be extended to some structurally related compounds.