D. Riendeau, J. Falgueyret, J. Gravel
1997
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Journal
Advances in experimental medicine and biology
Abstract
Leukotriene A4 (LTA4) is a product of the 5-lipoxygenase reaction and a key intermediate in the biosynthesis of leukotrienes. LTA4 serves as a substrate for the enzymatic hydrolysis to leukotriene B4 or conjugation with glutathione to yield the peptidoleukotrienes. In addition, LTA4 undergoes a rapid non-enzymatic hydrolysis in aqueous solution at neutral pH with a half-time of few seconds. The hydrolysis products have been identified fifteen years ago and shown to correspond mainly to an equimolar mixture of 6-trans-LTB4 and 6-trans-12-epi-LTB4 with smaller amounts of 5,6-dihydroxyeicosatetraenoic acids (5,6-diHETE) (1,2).