Sarah Rioton, Aurélie Orliac, Z. Antoun
May 22, 2015
Citations
0
Influential Citations
19
Citations
Journal
Organic letters
Abstract
3-Substituted 2-(trifluoromethyl)piperidines B were synthesized by ring expansion of (trifluoromethyl)prolinols A, which were obtained from L-proline via an aziridinium intermediate C. The ring opening of the (trifluoromethyl)aziridinium intermediate by different nucleophiles is regio- and diastereoselective.