P. Astles, T. Brown, P. Cox
1997
Citations
1
Influential Citations
23
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract A series of phenylguanidines which bind to the C5a receptor has been developed. The lead compound 1 (IC50=30μM), discovered through random screening, has been modified to provide 32 (RPR121154) with submicromolar activity. This compound was shown to further elicit functional antagonism in a human neutrophil C5a stimulated respiratory burst assay.