M. Bachelet
Feb 2, 2020
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Reproducibility. Transparency. Rigor. These words are being used more often in scientific and popular circles. As scientists we strive to con-duct rigorous research. We expect that are experiments are reproducible, but are we doing enough? As a field, toxicology needs to continue to make our research as useful as possible. This means producing rigorous and reproducible results. We must also be transparent and helpful as we describe our methods. Authors must ask themselves if they are providing sufficient detail for others to replicate their results. At Toxicological Sciences, we remain committed to these ideals. We are in the process of expanding our guidelines and instructions to assure that when you Look Inside ToxSci that you are seeing the most rigorous and reproducible research in the field of toxicology.—Gary W. concentrations as low as 100nM. They correlated these decreases to inhibition of mitochondrial complex I and III. The authors sug-gest that mitochondrial-induced dysfunction may lead to pancreatic beta cell injury, which could increase the risk for T2D. These data set the stage for larger scale in vivo studies, and future studies that may discern the anti-affective ability of antidepressants from their ability to induce mitochondrial dysfunction. Abstract—Brian S. Cummings Pyrethroids, Constitutive Androstane and Tumors: Elucidating the mode of toxic action for any chemical requires diverse model systems. In some cases, species differ-ences can exist, which can complicate the process of determin-ing the mechanisms by which specific chemicals cause toxicity. In the studies by Okuda et al. (pp. 412), the role of the constitutive androstane receptor (CAR) in modulating hepatic cell proliferation was examined using a CAR knockout rat model. Administration of the pyrethroid momfluorothrin caused hepato-megaly due to hypertrophy and increased replicative DNA synthesis; effects that were similar to those observed by administration of the prototypical CAR ligand phenobarbital and somewhat mitigated in the CAR knockout rats. Given the essen-tial role of mitogenicity in mediating liver tumorigenesis, results from these studies provide evidence that liver tumorigenesis induced by momfluorothrin in rats may be mediated at least in part by CAR. These results will be useful for future risk assessment of momfluorothrin. View Abstract —Jeffrey M. Peters