H. Furuta, D. Magda, J. Sessler
1991
Citations
0
Influential Citations
57
Citations
Journal
Journal of the American Chemical Society
Abstract
The synthesis and binding properties of two types of amine-containing, cytosine-based ditopic receptors, 4-amino-1-[4-[N,N-bis [2-(N,N-diethylamino) ethyl] amino] butyl]-2(1H)-pyrimidione (1) and 4-amino-1-[4-(N,N-diethylamino) butyl]-2 (1H)-pyrimidinone (2a), 4-amino-1-[5-(N,N-diethylamino) pentyl]-2(1H)-pyrimidinone (2b), and 4-amino-1-[6-(N,N-diethylamino) hexyl]-2(1H)-pyrimidinone (2c), are described. The four cytosine derivatives 1 and 2a-c contain both base pairing and ammonium electrostatic binding subunits. As such, they were expected to act as efficient ditopic receptors for the complexation of guanosine 5'-monophosphate (GMP), a prototypical purine-derived substrate